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Black Diamond Therapeutics is a precision oncology medicine company pioneering the development of novel MasterKey therapies. Black Diamond is addressing the significant unmet need for novel precision oncology therapies for patients with genetically defined cancers who have limited treatment options. Black Diamond is built upon a deep understanding of cancer genetics, onco-protein function, and drug discovery

Black Diamond Therapeutics Presents Preclinical Data on BDTX-1535 and BDTX-4933 at the 34th ...

Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of MasterKey therapies, today announced the presentation of three posters reporting new preclinical data on BDTX-1535 and BDTX-4933 at the 34th European Organisation for Research and Treatment of Cancer—National Cancer Institute—American Association for Cancer Research (EORTC-NCI-AACR) Symposium on Molecular Targets and Cancer Therapeutics being held in Barcelona, Spain. The poster presentations highlight new preclinical data demonstrating robust anti-tumor activity of both programs in a broad range of preclinical models of oncogene driven cancers

By Black Diamond Therapeutics, Inc
Published - Oct 26, 2022, 08:06 AM ET
Last Updated - Apr 23, 2024, 09:17 AM EDT
  • BDTX-1535 is an irreversible MasterKey inhibitor of multiple EGFR alterations that utilize similar activated oncogenic EGFR conformations to drive tumor cell growth in GBM and NSCLC
  • BDTX-1535 demonstrated potent systemic and CNS anti-tumor activity and survival benefit in multiple PDX models of GBM and NSCLC tumors driven by a family of EGFR alterations, including resistance mutations and EGFR amplification
  • BDTX-4933 is a MasterKey inhibitor of oncogenic isoforms of the RAF family, which demonstrated on-target cell growth inhibition in vitro and tumor growth regression in in vivo tumor models driven by oncogenic Class I, II and III BRAF alterations and NRAS mutations
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