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Ionis is pleased with the results of the Phase 2b B-Clear study and to see bepirovirsen advance to Phase 3 clinical studies for the potential to offer a first-in-class therapy for people with CHB, including the possibility of functional cures. With these clinically meaningful results, we believe bepirovirsen has the potential to provide significant benefit to the millions of people with this chronic disease," said Richard S. Geary, Ph.D., executive vice president, drug development at Ionis

Ionis announces positive data from GSK's Phase 2b clinical study of bepirovirsen

Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that GSK presented positive end of study data from the Phase 2b B-Clear study of bepirovirsen (formerly IONIS-HBVRx), an investigational antisense oligonucleotide treatment for patients with chronic hepatitis B virus (CHB). The results showed that treatment with bepirovirsen resulted in sustained clearance of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA for 24 weeks after end of bepirovirsen treatment in people with CHB. The study results were presented at the American Association for the Study of Liver Diseases' (AASLD) The Liver Meeting® in Washington, DC

By AP News
Published - Nov 08, 2022, 01:55 PM ET
Last Updated - Mar 20, 2024, 03:07 PM EDT
  • GSK plans to advance bepirovirsen into Phase 3 development program in 1H 2023

    • CARLSBAD, Calif., Nov. 8, 2022 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that GSK presented positive end of study data from the Phase 2b B-Clear study of bepirovirsen (formerly IONIS-HBVRx), an investigational antisense oligonucleotide treatment for patients with chronic hepatitis B virus (CHB). The results showed that treatment with bepirovirsen resulted in sustained clearance of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA for 24 weeks after end of bepirovirsen treatment in people with CHB. The study results were presented at the American Association for the Study of Liver Diseases' (AASLD) The Liver Meeting® in Washington, DC.

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