Past COVID infections may help protect against certain colds. Could it lead to better vaccines?

If you’ve been sick with COVID-19, you may have some protection against certain versions of the common cold.

A new study suggests previous COVID-19 infections lower the risk of getting colds caused by milder coronavirus cousins, which could provide a key to broader COVID-19 vaccines.

“We think there’s going to be a future outbreak of a coronavirus,” said Dr. Manish Sagar, senior author of the study published Wednesday in the journal Science Translational Medicine. “Vaccines potentially could be improved if we could replicate some of the immune responses that are provided by natural infection.”

The study looked at COVID-19 PCR tests from more than 4,900 people who sought medical care between November 2020 and October 2021. After controlling for things like age, gender and preexisting conditions, Sagar said he and his colleagues found people previously infected with COVID-19 had about a 50% lower chance of having a symptomatic coronavirus-caused common cold compared with people were were, at the time, fully vaccinated and hadn't yet gotten COVID-19.