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San Francisco 49ers running back Christian McCaffrey (23) runs against Buffalo Bills safety Taylor Rapp, bottom, during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Dec. 1, 2024. (AP Photo/Adrian Kraus)

Christian McCaffrey's season 'potentially' over after knee injury in 49ers' loss to Bills

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night

By JOHN WAWROW
Published - Dec 02, 2024, 02:06 AM ET
Last Updated - Dec 16, 2024, 05:10 PM EST

ORCHARD PARK, N.Y. (AP) — San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament, which connects the thigh bone to the shin. He said he had no timetable for McCaffrey’s return but acknowledged the All-Pro’s season could be over.

“I think PCL is usually a couple weeks, but I’m not exactly sure yet,” Shanahan said.

It’s the latest setback in a frustrating season for the 2023 offensive player of the year, who missed the Niners’ first eight games with Achilles tendinitis and has not been his usual explosive self since returning. And it's another blow for a team that has battled injuries all season, was missing five starters against Buffalo and dropped its third straight.

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